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Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage
Published on: February 15, 2020
Oxidative stress in primary open-angle glaucoma.
Vicente Zanon-Moreno1, Pilar Marco-Ventura, Antonio Lleo-Perez
1Ophthalmologic Research Unit Santiago Grisolia, Dr Peset Universitary Hospital, Valencia, Spain. zanon_vicmor@gva.es
Journal of Glaucoma
|June 17, 2008
Summary
Primary open-angle glaucoma (POAG) shows increased oxidative stress and decreased antioxidant activity in aqueous humor. These findings suggest oxidative stress plays a role in POAG development.
Area of Science:
- Ophthalmology
- Biochemistry
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Oxidative stress is implicated in various ocular diseases, but its specific role in POAG requires further elucidation.
Purpose of the Study:
- To investigate the levels of oxidative stress and antioxidant status in the aqueous humor of patients with POAG.
- To determine if oxidative stress markers correlate with glaucoma risk factors.
Main Methods:
- A case-control study compared 50 POAG patients with 40 cataract patients.
- Aqueous humor samples were analyzed for malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) as a marker of lipid peroxidation and for total antioxidant status.
- Statistical analyses assessed MDA-TBARS and antioxidant status in relation to glaucoma.
Main Results:
- Patients with POAG exhibited significantly higher levels of MDA-TBARS compared to the cataract group (P<0.001).
- Total antioxidant activity in the aqueous humor was significantly lower in POAG patients than in cataract patients (P<0.001).
Conclusions:
- Aqueous humor analysis is a viable method for assessing oxidative and antioxidant status in pathological conditions.
- Elevated oxidative stress and reduced antioxidant capacity in the aqueous humor of POAG eyes suggest a significant role in the disease's pathogenesis.
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