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Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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Related Experiment Video

Updated: Jul 4, 2026

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E
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Published on: September 26, 2019

[Microscopic colitis: collagenous colitis and lymphocytic colitis].

Denis Chatelain1, Nassima Mokrani, Jean-François Fléjou

  • 1Service d'anatomie pathologique, CHU d'Amiens, Place Victor-Pauchet, 80054 Amiens cedex 01. Chatelain.denis@chu-amiens.fr

Annales De Pathologie
|June 17, 2008
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Summary

Microscopic colitis, including lymphocytic colitis and collagenous colitis, causes chronic watery diarrhea. Diagnosis requires biopsy, and while budesonide is a common treatment, recurrences are frequent.

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Area of Science:

  • Gastroenterology
  • Histopathology
  • Internal Medicine

Context:

  • Microscopic colitis is a chronic inflammatory bowel disorder characterized by watery diarrhea and abdominal pain, often with normal colonoscopy findings.
  • It encompasses two distinct histological subtypes: collagenous colitis (thickened collagen band >10 microm) and lymphocytic colitis (intraepithelial lymphocytes >20 per 100 epithelial cells).

Purpose:

  • To summarize the current understanding of microscopic colitis, including its classification, clinical presentation, diagnostic criteria, and treatment challenges.
  • To highlight the diagnostic importance of histopathology in differentiating between collagenous and lymphocytic colitis.

Summary:

  • Microscopic colitis presents with chronic watery diarrhea and abdominal pain, but colonoscopy typically appears normal.
  • Definitive diagnosis relies on colonic biopsy findings, distinguishing between collagenous colitis (subsurface collagen band) and lymphocytic colitis (intraepithelial lymphocytes).
  • Etiology remains largely unknown, though drug-induced cases exist. Budesonide is a common treatment, but frequent recurrences pose a management challenge.

Impact:

  • Provides a concise overview for clinicians and researchers on microscopic colitis diagnosis and management.
  • Emphasizes the need for further research into the unknown causes and effective long-term treatments for microscopic colitis to reduce recurrence rates.