Relationship between serum progesterone and tumor necrosis factor production in postmenopausal women undergoing
Urszula Stopińska-Głuszak1, Jarosław Jóźwiak, Dariusz Radomski
1Department of Histology and Embryology, Center of Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
Fertility and Sterility
|June 17, 2008
Abstract:
Changes in tumor necrosis factor (TNF) production by lipopolysaccharide-stimulated peripheral blood mononuclear cells significantly correlated with serum P levels in postmenopausal women subjected to estrogen/medroxyprogesterone therapy. This may suggest that low physiologic or hormone therapy-related changes of serum P in healthy postmenopausal women may affect an ability of peripheral blood mononuclear leukocytes to produce TNF, thus having an impact on a variety of TNF-dependent physiologic and pathologic phenomena.
