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Related Experiment Videos

Exploring the structure and function paradigm.

Oliver C Redfern1, Benoit Dessailly, Christine A Orengo

  • 1Department of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom.

Current Opinion in Structural Biology
|June 17, 2008
PubMed
Summary
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Structural genomics yields novel protein folds, but function remains unclear. This review explores structural novelty

Area of Science:

  • Structural Biology
  • Bioinformatics
  • Protein Science

Background:

  • Structural genomics initiatives have increased novel protein fold discoveries in the Protein Data Bank.
  • Many newly determined protein structures lack experimentally confirmed functional annotations.
  • The relationship between protein structure and function is complex and requires further investigation.

Purpose of the Study:

  • To reassess the definition and implications of structural novelty in proteins.
  • To examine the relevance of structural novelty to the protein structure-function paradigm.
  • To discuss recent advancements in predicting protein function from structure and sequence.

Main Methods:

  • Review of current literature on protein structure determination and functional annotation.

Related Experiment Videos

  • Analysis of advances in structure-based and sequence-based protein function prediction.
  • Discussion of methods for clustering protein superfamilies into biologically relevant groups.

    • Main Results:

    • Structural novelty's meaning needs re-evaluation in the context of function.
    • Predictive methods are improving the understanding of function from structure.
    • Sequence-based clustering aids in identifying functionally coherent protein groups.

    Conclusions:

    • Integrating structural data with functionally coherent groups is crucial.
    • A deeper understanding of the protein structure-function relationship is achievable.
    • Bridging the gap between novel structures and functional annotation remains a key challenge.