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Updated: Jul 4, 2026

Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota
Published on: May 23, 2025
Mechanistic insights into glycosidase chemistry
David J Vocadlo1, Gideon J Davies
1Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, V5A 1S6, Canada. dvocadlo@sfu.ca
Abstract:
The enzymatic hydrolysis of the glycosidic bond continues to gain importance, reflecting the critically important roles complex glycans play in health and disease as well as the rekindled interest in enzymatic biomass conversion. Recent advances include the broadening of our understanding of enzyme reaction coordinates, through both computational and structural studies, improved understanding of enzyme inhibition through transition state mimicry and fascinating insights into mechanism yielded by physical organic chemistry approaches.
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