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Some approaches to prevention of endogenous formation of N-nitrosamines in humans
P P Dikun1, V B Ermilov, I A Shendrikova
1N.N. Petrov Research Institute of Oncology of the USSR, Ministry of Health, Leningrad.
IARC Scientific Publications
|January 1, 1991
Abstract:
In a series of experiments on formation of N-nitrosamines from precursors in the gastric juice, we investigated individual nitrosation capacity and the influence of inhibitors on this process. In the presence of a molar ratio of 2:1 ascorbic acid:NaNO2, we found increased nitrosamine formation in 34% of gastric juice samples. Ferulic acid and caffeic acid generally suppressed nitrosation at high concentrations and stimulated it at low concentrations. The concentration at which the transition from a stimulating to an inhibitory effect occurs depends on individual differences in the gastric juice.