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Updated: Jul 4, 2026

Intratracheal Administration of Dry Powder Formulation in Mice
Published on: July 25, 2020
[Development of inhalation powder formulation of gentamicin sulphate]
Abstract:
Aminoglycosides, including gentamicin, are considered among the most useful classes of antibiotics for treating Pseudomonas aeruginosa infections. The major drawback of aminoglycosides is the need for their relatively high-dose intravenous administration, which carries the potential for systemic toxicity. Granulometry analysis of gentamicin sulfate powder (substance) has shown, that generally it consists of large particles, and thus is not suitable for inhalation. Six different inhalation composition containing gentamicin sulfate has been developed, one of which showed the best inhalation properties. Technological chart and pilot Master formula for inhalation gentamicin sulfate composition delivered via Handi Haler have been developed.
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