Related Experiment Video
Updated: Jul 4, 2026

05:37
Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
8-Amino guanine accelerates tetramolecular G-quadruplex formation
Julien Gros1, Anna Aviñó, Jaime Lopez de la Osa
1Muséum National d'Histoire Naturelle (MNHN) USM 503, INSERM U565, CRNS UMR 5153, 43 rue Cuvier CP26, F-75231, Paris Cedex 05, France.
Abstract:
We demonstrate here that 8-amino guanine () strongly accelerates quadruplex formation, which makes this nucleobase the most attractive replacement for guanine in the context of tetramolecular parallel quadruplexes.
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