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Updated: Jul 4, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Is transesophageal echocardiography still necessary to exclude patent foramen ovale?
M Zuber1, F Cuculi, E Oechslin
1Division of Cardiology, Kantonsspital Luzern, Luzern, Switzerland. michel.zuber@bluewin.ch
Insights
High-end transthoracic echocardiography (TTE) accurately detects interatrial shunts, including patent foramen ovale (PFO), using contrast. This may establish TTE as a preferred diagnostic method over transesophageal echocardiography (TEE).
Area of Science:
- Cardiology
- Medical Imaging
- Diagnostic Techniques
Background:
- Current guidelines recommend transesophageal echocardiography (TEE) as the gold standard for diagnosing interatrial shunts.
- There is a need to evaluate alternative, less invasive diagnostic methods.
Purpose of the Study:
- To assess the accuracy of high-end transthoracic echocardiography (TTE) in excluding interatrial shunts.
- To compare TTE with TEE for shunt detection.
Main Methods:
- Prospective study involving both TTE and TEE with second harmonic imaging.
- Utilized color Doppler and contrast echocardiography to detect left-to-right (L/R) or right-to-left (R/L) shunts.
- Included patients with unexplained cerebrovascular incidents or new valvular/myocardial disease.
Main Results:
- An interatrial shunt was identified in 200 out of 438 patients (45.7%).
- Contrast echocardiography with a Valsalva maneuver detected 95% of shunts using both TTE and TEE.
- TTE uniquely identified 5% of shunts that were missed by TEE.
Conclusions:
- High-end transthoracic contrast-echocardiography can reliably demonstrate patent foramen ovale (PFO).
- TTE shows potential to become the preferred diagnostic method for PFO.
- Further studies are warranted to confirm these findings.
Objectives:
Current guidelines still recommend transesophageal echocardiography (TEE) as reference method to diagnose interatrial shunts. The aim was to test the accuracy of high-end transthoracal echocardiography (TTE) to exclude inter-atrial shunts.
Methods:
Prospective TTE and TEE study with second harmonic imaging to determine left-to-right shunt (L/R) by both colour Doppler or R/L by contrast echocardiography in patients with unexplained cerebrovascular incidents or newly detected valvular or myocardial disease.
Results:
An inter-atrial shunt was diagnosed in 200 of 438 analyzed patients (117 males). Colour Doppler echocardiography visualized a shunt in 67 patients (34%) on TTE vs. 84 (42%) patients on TEE (p <0.0001). However injection of agitated blood with a valsalva maneuver detected 190 (95%) interatrial shunts by both TTE and TEE, but 10 shunts (5%) only by TTE.
Conclusions:
Our study shows that patent foramen ovale can safely be demonstrated with high-end transthoracic contrast- echocardiography. If additional studies confirm our results, TTE has the potential to become the method of choice in the diagnosis of PFO.
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