Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mapping the human protein interactome.

Daniel Figeys1

  • 1The Ottawa Institute of Systems Biology, The Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. dfigeys@uottawa.ca

Cell Research
|June 25, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MetaTree: an interactive web platform for aligned hierarchical data visualization and multi-group comparison.

BMC bioinformatics·2026
Same author

Individual variability shapes ex vivo responses to resistant starch in inflammatory bowel disease derived microbiomes.

NPJ biofilms and microbiomes·2026
Same author

MetaDIA: A DDA-free Database Reduction Strategy for DIA Human Gut Metaproteomics.

Genomics, proteomics & bioinformatics·2026
Same author

Microbiome-dependent functional responses to structurally distinct oligosaccharides revealed by metaproteomics.

NPJ biofilms and microbiomes·2025
Same author

Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs.

Nature communications·2025
Same author

Peptide abundance correlations in metaproteomics enhance taxonomic and functional analysis of the human gut microbiome.

NPJ biofilms and microbiomes·2025
Same journal

Smooth emotional response: amygdalar neurovascular coupling drives stress encoding.

Cell research·2026
Same journal

Liquid surrogates of spatial tumor ecosystems.

Cell research·2026
Same journal

MitoCatch directs mitochondria delivery and prevents cell degeneration.

Cell research·2026
Same journal

Structural basis of sex pheromone detection in aphids.

Cell research·2026
Same journal

Tagging the Tank: Ubiquitin-mediated clearance of cellular energy reserves.

Cell research·2026
Same journal

One-step generation of semi-cloned zebrafish carrying a defined genetic modification.

Cell research·2026
See all related articles

Mapping biomolecular interactions is crucial for understanding biological functions and advancing systems biology. This review focuses on protein-protein interactions, highlighting the need for large-scale human interactome mapping and discussing current strategies.

Area of Science:

  • Biochemistry and Molecular Biology
  • Systems Biology
  • Bioinformatics

Background:

  • Biomolecular interactions are fundamental to cellular functions.
  • Understanding these interactions is key to deciphering biological roles and developing systems biology approaches.
  • While protein-protein interaction mapping has advanced in various species, large-scale human mapping remains less explored.

Purpose of the Study:

  • To review the current state of protein interaction mapping techniques.
  • To discuss the challenges and strategies for comprehensive human protein interactome mapping.
  • To emphasize the importance of human interactome data for biological and medical research.

Main Methods:

  • Literature review of protein interaction mapping methodologies.

Related Experiment Videos

  • Analysis of existing datasets and computational approaches for interactome reconstruction.
  • Discussion of experimental techniques and their limitations.

    • Main Results:

    • Protein interaction mapping has seen significant technological advancements.
    • The human interactome is vast and complex, requiring integrated mapping strategies.
    • Current methods face challenges in scalability, accuracy, and data integration.

    Conclusions:

    • Large-scale mapping of the human protein interactome is essential for systems biology.
    • A combination of experimental and computational approaches is needed for comprehensive mapping.
    • Addressing current challenges will accelerate our understanding of human biology and disease.