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[Duodenal ulcer in systemic mastocytosis]
1Medicinsk gastroenterologisk afdeling, Hvidovre Hospital, København.
Ugeskrift for Laeger
|July 1, 1991
Summary
Systemic mastocytosis can cause difficult-to-treat peptic ulcers. High gastric acid secretion with normal gastrin levels may indicate this rare condition.
Area of Science:
- Hematology
- Gastroenterology
- Endocrinology
Background:
- Systemic mastocytosis (SM) is a rare myeloproliferative neoplasm characterized by abnormal mast cell accumulation.
- Peptic ulceration is a known gastrointestinal manifestation, but its association with specific secretory profiles in SM requires further elucidation.
Observation:
- Two cases of systemic mastocytosis are presented, both exhibiting peptic ulceration.
- Patients presented with therapy-resistant peptic ulceration, prompting further investigation.
Findings:
- Gastric acid secretion studies revealed greatly raised values in both patients.
- Serum gastrin levels were within the normal range, despite significant hypersecretion.
Implications:
- Elevated gastric acid secretion coupled with normal serum gastrin in patients with refractory peptic ulcers should raise suspicion for systemic mastocytosis.
- This highlights the importance of considering systemic mastocytosis in the differential diagnosis of unexplained peptic ulcer disease.
- Early recognition and diagnosis of systemic mastocytosis can lead to timely management and potentially improved outcomes.