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[How to determine outcomes for clinical studies]
1Horten Zentrum für praxisorientierte Forschung und Wissenstransfer, Universitätsspital Zürich. milo.puhan@usz.ch
Therapeutische Umschau. Revue Therapeutique
|June 28, 2008
Summary
Choosing appropriate outcomes is crucial for clinical studies. Selecting patient-important outcomes or physiological parameters based on research questions ensures accurate interpretation and facilitates evidence synthesis.
Area of Science:
- Clinical research methodology
- Biomedical study design
Background:
- Outcomes are essential for interpreting clinical study results.
- The choice of outcomes significantly influences study interpretation and analysis.
- Aligning outcomes with research questions is critical for study validity.
Purpose of the Study:
- To emphasize the importance of selecting appropriate outcomes in clinical research.
- To guide investigators in choosing between patient-important outcomes and physiological parameters.
- To highlight the impact of outcome selection on study design and evidence synthesis.
Main Methods:
- Literature review on outcome selection in clinical studies.
- Analysis of the impact of different outcome types on study design and confounding factors.
- Consideration of existing literature for outcome selection.
Main Results:
- Outcome selection directs the interpretation of clinical studies.
- Patient-important outcomes are preferred for clinical aspects, while physiological parameters suit mechanistic research.
- Outcome choice affects study design, analysis, and potential confounding factors.
Conclusions:
- Investigators must carefully select outcomes that align with their research questions.
- Considering existing literature facilitates the appreciation and summary of overall evidence.
- Appropriate outcome selection enhances the clarity and utility of clinical study findings.
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