[The significance of disruption of erythrocyte membrane protein and lipid composition on the development of a...

Protein and lipid composition of erythrocyte membranes as well as loss of erythrocyte filtrability were studied in two experimental models: staphylococcal toxicosis and post-ischemic syndrome. Lipid spectrum of erythrocytes was studied in 16 experiments, protein composition--in 28 experiments and deformation of erythrocytes--in 46 experiments. Considerable destruction of erythrocyte membrane protein moiety and of lipid composition were found under extreme conditions involving distinct loss of phospholipid bilayer and decrease in content of main high molecular proteins. These impairments of erythrocyte membranes and a decrease in erythrocyte flow properties may be referred as principal reasons for development of microcirculation disturbance and of microvascular channel blockade. The alterations observed appear to be responsible for occurrence of components with various ability to aggregation in body fluid media as well as for development of disseminated intravascular coagulation in microcirculation.