Related Experiment Video
Updated: Jul 4, 2026
10:12
Neisseria meningitidis Infection of Induced Pluripotent Stem-Cell Derived Brain Endothelial Cells
Published on: July 14, 2020
[Acute meningoencephalitis revealing a Behçet's disease]
N Libert1, S Cremades, C Pelletier
1Service d'anesthésie-réanimation, HIA Bégin, 69, avenue de Paris, 94160 Saint-Mandé, France. nicolaslibert@free.fr
La Revue De Medecine Interne
|July 1, 2008
Summary
Aseptic meningoencephalitis in a 69-year-old man was initially treated for infection. Diagnosis shifted to Behçet's disease, with high-dose steroids proving effective for neuro-Behçet's disease.
Area of Science:
- Neurology
- Immunology
- Internal Medicine
Background:
- Aseptic meningoencephalitis presents a diagnostic challenge, often initially mistaken for infectious causes.
- Behçet's disease is a rare multisystem inflammatory disorder with potential neurological manifestations.
Observation:
- A 69-year-old male patient in intensive care presented with aseptic meningoencephalitis.
- Initial anti-infectious treatment was ineffective, prompting a search for noninfectious etiologies.
Findings:
- Behçet's disease was diagnosed during hospitalization.
- High-dose steroid therapy demonstrated rapid efficacy, supporting the diagnosis of neuro-Behçet's disease.
Implications:
- This case highlights the importance of considering Behçet's disease in refractory aseptic meningoencephalitis.
- Early diagnosis and appropriate immunosuppressive therapy are crucial for managing neuro-Behçet's disease.
- Highlights the diagnostic challenges and treatment outcomes in neuroinflammatory disorders.
Related Concept Videos
01:19Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
01:22Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
01:24Bacterial Meningitis
Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
01:25Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
01:18Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...