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Topical capsaicin application causes cold hypersensitivity in awake monkeys.

Hiroshi Kamo1, Kuniya Honda, Junichi Kitagawa

  • 1Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo, Japan.

Journal of Oral Science
|July 1, 2008
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Summary

Capsaicin application to facial skin sensitizes cold receptors in monkeys. This study shows capsaicin (a TRPV1 agonist) reversibly increases sensitivity to cold stimuli, impacting detection in behaving animals.

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Area of Science:

  • Neuroscience
  • Sensory Physiology

Background:

  • Trigeminal ganglion neurons co-express TRPV1 and TRPA1 receptors after inflammation.
  • Capsaicin is known to activate TRPV1 receptors.

Purpose of the Study:

  • To investigate if capsaicin sensitizes cold receptors in awake, behaving monkeys.
  • To assess the effect of capsaicin on cold detection thresholds.

Main Methods:

  • Two monkeys were trained to detect changes in facial cold stimuli.
  • Behavioral responses (escape/hold-through trials, latency) were measured after topical capsaicin application.

Main Results:

  • Capsaicin treatment increased escape trials and decreased hold-through trials.
  • Detection latency for cold stimuli was significantly reduced post-capsaicin.
  • These findings indicate capsaicin induces cold hypersensitivity.

Conclusions:

  • Topical capsaicin application reversibly sensitizes facial cold receptors in monkeys.
  • This suggests a role for TRPV1 in modulating cold perception and hypersensitivity.