Related Experiment Video
Updated: Jul 4, 2026

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
[Investigation on the usage and prescription of adrenaline self-injector against anaphylaxis]
Takanori Imai1, Chizuko Sugizaki, Motohiro Ebisawa
1Department of Pediatrics, National Hospital Organization Sagamihara National Hospital. ta-imai@sagamihara-hosp.gr.jp
Background:
In Japan Adrenaline self injector (ASJ) became available for patients with anaphylaxis including children in 2005. Countermeasure against anaphylaxis in Japan is far behind international standards, and understanding of anaphylaxis and its treatment by doctors is thought to be unsatisfactory level.
Methods And Subjects:
This investigation was carried out using questionnaire towards 1,196 doctors who had contributed nationwide survey of food allergy monitoring in 2005. The investigation was done on January in 2006. The questionnaire consisted of possession of registration as ASJ prescription doctor, prescription experience, indication of ASJ prescription, and timing for patients to use ASJ.
Results:
Seven hundred and seven replies were obtained out of 1,196 doctors, and 443 doctors (62.7%) were reported to be registered as an ASJ prescription doctors. Among 443 registered doctors, 209 doctors had experienced to prescribe ASJ. Only 88 percent of doctors accepted the cases with repeated anaphylaxis as criteria for absolute prescription of ASJ, and 41.6 percent of doctors accepted cases with history of anaphylaxis as the criteria. Timing by doctors to inject adrenaline was reported to be cases with circulatory symptom (93.7%), airway mucosa symptom (79.4%), and with respiratory symptom (56.6%),
Discussion:
Japanese doctors seem to have unsatisfactory level of knowledge of anaphylaxis . It is important for Japanese doctors to receive appropriate education on anaphylaxis and ASJ.
Related Concept Videos
Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...
Allergic Reactions: Anaphylaxis
Allergic Reactions
Adrenergic Agonists: Mixed-Action Agents
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
Adrenergic Agonists: Direct-Acting Agents
These agents can be classified...
Adrenergic Agonists: Therapeutic Classification
Vasopressor or pressor agents: They increase blood pressure and function as cardiac stimulants. Examples include endogenous catecholamines (norepinephrine and dopamine) and synthetic agents (phenylephrine).
Bronchodilators: β2-agonists can relax bronchial muscles and widen airways. They are commonly used for treating obstructive pulmonary...

