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Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Exocytosis00:51

Exocytosis

Exocytosis is used to release material from cells. Like other bulk transport mechanisms, exocytosis requires energy.
Exocytosis00:50

Exocytosis

Exocytosis is a process that releases molecules outside the cell. Like other bulk transport mechanisms, exocytosis requires energy.
Exocytosis is the opposite of endocytosis, which brings molecules inside the cell. Sometimes, the released materials are signaling molecules. For example, neurons typically use exocytosis to release neurotransmitters. Cells also use exocytosis to insert proteins such as ion channels into their cell membranes, secrete proteins for use in the extracellular matrix, or...
Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis01:18

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

Vesicular transport is a cellular process that encompasses the engulfment of particles or dissolved substances by cells. It involves endocytosis, transcytosis, and exocytosis.
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell eating"). Pinocytosis is...

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Related Experiment Video

Updated: Jul 4, 2026

Isolation and Characterization of Exosomes from Skeletal Muscle Fibroblasts
06:27

Isolation and Characterization of Exosomes from Skeletal Muscle Fibroblasts

Published on: May 16, 2020

Exosomes.

Joost P J J Hegmans1, Peter J Gerber, Bart N Lambrecht

  • 1Department of Pulmonary Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands.

Methods in Molecular Biology (Clifton, N.J.)
|July 2, 2008
PubMed
Summary
This summary is machine-generated.

Exosomes, small vesicles from cells, act as messengers and can influence immune responses. These cell-derived vesicles show potential in cancer immunotherapy and understanding cell-to-cell communication.

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Last Updated: Jul 4, 2026

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06:27

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Purification and microRNA Profiling of Exosomes Derived from Blood and Culture Media

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Isolation of Extracellular Vesicles from Murine Bronchoalveolar Lavage Fluid Using an Ultrafiltration Centrifugation Technique
09:18

Isolation of Extracellular Vesicles from Murine Bronchoalveolar Lavage Fluid Using an Ultrafiltration Centrifugation Technique

Published on: November 9, 2018

Area of Science:

  • Cell Biology
  • Immunology
  • Biochemistry

Background:

  • Exosomes are natural membrane vesicles secreted by diverse cell types via exocytosis.
  • They function in removing cellular waste and mediating intercellular communication by transferring proteins.
  • Emerging roles suggest exosomes influence immune tolerance, NK cell activity, T cell apoptosis, and metastasis.

Purpose of the Study:

  • To explore the multifaceted biological functions of exosomes.
  • To investigate the potential of exosomes in modulating immune responses.
  • To evaluate exosomes as a therapeutic tool in cancer treatment.

Main Methods:

  • Literature review of exosome biology and function.
  • Analysis of exosome involvement in intercellular signaling.
  • Assessment of exosome-mediated immune modulation and therapeutic potential.

Main Results:

  • Exosomes facilitate intercellular communication through membrane fusion and cargo transfer.
  • Tumor-derived exosomes can evade immune surveillance by shedding antigens and inducing immune cell dysfunction.
  • Dendritic cell-derived exosomes exhibit potential as cell-free immunotherapeutic agents against cancer.

Conclusions:

  • Exosomes play significant roles in cellular communication and immune regulation.
  • Further research is needed to fully elucidate the complex functions of exosomes.
  • Exosomes represent a promising frontier in cell-based therapies and understanding biological responses.