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Related Concept Videos

Supercritical Fluid Chromatography01:18

Supercritical Fluid Chromatography

Supercritical fluid chromatography (SFC) provides a beneficial substitute for gas chromatography (GC) and liquid chromatography (LC) for certain samples because it merges the top attributes of both techniques. SFC allows the separation and analysis of compounds that GC or LC does not easily manage. These compounds are traditionally nonvolatile or thermally unstable, making GC unsuitable and lacking functional groups required for HPLC analysis.
SFC utilizes a supercritical fluid mobile phase,...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
Production of Pharmaceuticals01:30

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Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the appropriate...
Pharmaceutical Equivalents01:26

Pharmaceutical Equivalents

As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.

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Supercritical Nitrogen Processing for the Purification of Reactive Porous Materials
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Are pharmaceutics really going supercritical?

Irene Pasquali1, Ruggero Bettini

  • 1Department of Pharmacy, University of Parma, 43100 Parma, Italy.

International Journal of Pharmaceutics
|July 4, 2008
PubMed
Summary
This summary is machine-generated.

Supercritical fluid technology offers innovative pharmaceutical applications, including particle engineering and drug delivery systems. This review highlights recent advances and future potential for advanced drug formulation and manufacturing.

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Area of Science:

  • Pharmaceutical Technology
  • Chemical Engineering
  • Materials Science

Background:

  • Supercritical fluids (SCFs) possess unique properties tunable by pressure and temperature.
  • Their application in pharmaceuticals is expanding due to environmental and efficiency benefits.
  • Traditional pharmaceutical processes often face limitations addressed by SCFs.

Purpose of the Study:

  • To critically review recent advances in supercritical fluid applications within the pharmaceutical industry.
  • To provide insights into the future trajectory of SCF technology in drug development and manufacturing.
  • To consolidate diverse SCF-based pharmaceutical processes for a comprehensive overview.

Main Methods:

  • Literature review of recent scientific publications on SCF applications in pharmaceuticals.
  • Critical analysis of processes including particle engineering, complexation, coating, and sterilization.
  • Discussion of emerging SCF-based techniques for drug formulation and delivery.

Main Results:

  • Supercritical fluid technology enables precise control over particle size and crystallinity.
  • SCFs facilitate the formation of stable cyclodextrin complexes and liposomes.
  • Advanced applications include tissue engineering, sterilization, and efficient solvent removal.

Conclusions:

  • Supercritical fluid technology presents a versatile and sustainable platform for pharmaceutical innovation.
  • Continued research and development will likely expand SCF applications in drug formulation, delivery, and manufacturing.
  • This technology holds significant promise for improving drug efficacy and production processes.