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Updated: Jul 3, 2026
07:14
Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
Flipping the paradigm on malaria transmission-blocking vaccines
Rhoel R Dinglasan1, Marcelo Jacobs-Lorena
1Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. rdinglas@jhsph.edu
Trends in Parasitology
|July 5, 2008
Summary
Malaria transmission-blocking vaccines (TBVs) are shifting focus from parasite targets to the Anopheles mosquito vector. This review explores mosquito-based TBVs for future malaria control strategies.
Area of Science:
- Malariology
- Vaccinology
- Vector Biology
Background:
- Transmission-blocking vaccines (TBVs) aim to prevent malaria spread.
- Traditional TBV research focused on parasite sexual stages for over 20 years.
- A novel approach targets antigens within the Anopheles mosquito vector.
Purpose of the Study:
- To review the current knowledge on mosquito-based TBVs.
- To discuss the potential of targeting the mosquito vector for malaria control.
Main Methods:
- Literature review of research on mosquito-based transmission-blocking vaccines.
- Analysis of the paradigm shift in TBV development.
Main Results:
- An emerging strategy targets antigens in the Anopheles mosquito, flipping the traditional approach.
- This review synthesizes current findings on mosquito-based TBV research.
Conclusions:
- Mosquito-based TBVs represent a promising new avenue for malaria prevention.
- Further research into targeting the vector is crucial for future vaccine development and malaria eradication efforts.
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