Related Experiment Video
Updated: Jul 3, 2026

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
Published on: September 11, 2017
Inhibitory ITAMs: a matter of life and death
Fabiano Pinheiro da Silva1, Meryem Aloulou, Marc Benhamou
1INSERM U699, University of Paris 7, Paris F-75018, France.
Abstract:
The balance between activating and inhibitory signals is essential to control immune responses to microorganisms. Innate and adaptive immune responses are regulated by receptors that signal through either an immunoreceptor tyrosine-based activation motif (ITAM) or an immunoreceptor tyrosine-based inhibitory motif (ITIM). When clustered, these motifs are, respectively, responsible for activating and inhibitory signals. Recently, the concept of inhibitory ITAM (ITAM(i)) has emerged as a new means to negatively control the immune response. In this Opinion, we will discuss the ability of Escherichia coli to evade the immune system by eliciting ITAM(i) function through FcgammaRIII (CD16) on phagocytes leading to uncontrolled systemic infection and sepsis. Elucidating such mechanisms will open opportunities for specific therapeutic manipulation of ITAM(i)-based signaling pathways.
More Related Videos
08:23Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain
Published on: May 12, 2018
14:47Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
Published on: April 21, 2023
Related Concept Videos
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Feedback Inhibition
Cellular Injury IlI: Cellular Death
Cellular Injury IV: Necrosis
Cellular Injury I: Introduction
Resting Membrane Potential
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...