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Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium
Published on: May 18, 2021
The moonlighting enzyme CD13: old and new functions to target
1The Feinstein Institute for Medical Research, Autoimmune Disease Center, 350 Community Drive, Manhasset, NY 11030, USA. pminaoso@nshs.edu
Trends in Molecular Medicine
|July 8, 2008
Summary
Aminopeptidase N (CD13) has diverse functions beyond enzymatic activity. Understanding these roles is crucial for developing effective CD13-targeting therapies and avoiding complications.
Area of Science:
- Biochemistry
- Molecular Biology
- Pharmacology
Background:
- Aminopeptidase N (CD13) is an ectoenzyme with known enzymatic functions.
- CD13 also possesses critical non-enzymatic functions that are often overlooked.
- Numerous CD13-targeting agents are in development, with some in clinical trials.
Purpose of the Study:
- To review the diverse functions of CD13 and their underlying mechanisms.
- To identify knowledge gaps crucial for interpreting CD13-targeting agent efficacy.
- To guide the rational design of novel CD13-based therapeutics.
Main Methods:
- Literature review of published studies on Aminopeptidase N (CD13).
- Analysis of enzymatic and non-enzymatic functions of CD13.
- Evaluation of current and emerging CD13-targeting therapeutic strategies.
Main Results:
- CD13 exhibits a wide range of biological activities independent of its enzymatic properties.
- Existing CD13-targeting tools may have efficacy influenced by these unrecognized functions.
- Potential for unexpected complications due to manipulation of CD13's multifaceted roles.
Conclusions:
- A comprehensive understanding of all CD13 functions is essential for therapeutic development.
- Further research is needed to elucidate CD13's biological relevance and mechanisms.
- Rational design of CD13-targeting agents requires consideration of both enzymatic and non-enzymatic activities.
