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Stereoselective synthesis of (-)-amphidinolide E

Chan Hyuk Kim1, Hyo Jung An, Won Kyo Shin

  • 1Department of Chemistry, Seoul National University, Seoul 151-747, Korea.

Chemistry, an Asian Journal
|July 8, 2008
PubMed
Summary

The total synthesis of (-)-amphidinolide E was successfully achieved, incorporating a challenging stereocenter late in the process. Key reactions included radical cyclization, enyne metathesis, Kocienski-Julia coupling, and macrolactonization.

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