Investigation into the mechanism by which cyclodextrins influence transdermal drug delivery

Clifford L Kear1, Jing Yang, Donald A Godwin

  • 1College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA.

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Methods for Studying Drug Absorption: In vitro

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Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

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