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Updated: Jul 3, 2026

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
A microbiological assessment of silver fusidate, a novel topical antimicrobial agent
1Department of Medical Microbiology, Royal Free Hospital School of Medicine, Pond St., London NW3 2QG, UK.
Abstract:
The silver salt of fusidic acid is a novel antimicrobial agent. Against staphylococci, in vitro tests showed silver fusidate was more active than silver sulphadiazine, and the activities of the sodium and the silver salts of fusidic acid were correlated. Against streptococci, enterococci, clostridia, Candida albicans and a range of Gram-negative bacilli, silver fusidate was of similar activity to silver sulphadiazine. Silver fusidate at 1 g/l was bactericidal against eight strains of staphylococci, irrespective of their susceptibility to sodium fusidate. Emergence of resistance to silver fusidate was rare.
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