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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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Related Experiment Video

Updated: Jul 3, 2026

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Th17 cells in human disease.

Laura A Tesmer1, Steven K Lundy, Sujata Sarkar

  • 1Department of Internal Medicine, Division of Rheumatology, Rheumatic Disease Core Center, University of Michigan, Ann Arbor, MI 48109-5358, USA.

Immunological Reviews
|July 11, 2008
PubMed
Summary
This summary is machine-generated.

T-helper 17 (Th17) cells, a CD4(+) T-cell subset producing interleukin-17 (IL-17), are crucial in immune-mediated diseases. Targeting Th17 cells offers promising therapeutic potential but requires careful consideration of infection defense roles.

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Last Updated: Jul 3, 2026

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Published on: October 25, 2024

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Small RNA Transfection in Primary Human Th17 Cells by Next Generation Electroporation

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • T cells play a critical role in human immunity.
  • The discovery of T-helper 17 (Th17) cells has revised our understanding of T-cell functions.
  • Th17 cells are a distinct CD4(+) T-cell subset defined by interleukin-17 (IL-17) production.

Purpose of the Study:

  • To explore the role of Th17 cells in human diseases.
  • To compare Th17 cell biology in mice and humans.
  • To identify therapeutic targets related to Th17 cell activity.

Main Methods:

  • Comparative analysis of Th17 cell biology in human and mouse models.
  • Review of recent data on Th17 cell involvement in various diseases.
  • Investigation of cytokines, chemokines, and feedback mechanisms related to Th17 cells.

Main Results:

  • Th17 cells are implicated in the pathogenesis of immune-mediated diseases like psoriasis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and asthma.
  • Th17 cells may also play a role in tumorigenesis and transplant rejection.
  • Significant similarities and differences exist between mouse and human Th17 cell biology.

Conclusions:

  • Th17 cells are key players in numerous human diseases due to the inflammatory nature of IL-17.
  • Understanding human Th17 biology reveals disease mechanisms and highlights new therapeutic targets.
  • Therapies targeting Th17 cells show promise but must account for their role in host defense against infection.