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Dexamethasone cyclophosphamide pulse therapy in systemic lupus erythematosus: a case report
Ramji Gupta1, Sarthak Gupta, Vikas Khera
1Vidyasagar Institute of Mental Health and Neurosciences, New Delhi, India. drramjigupta@yahoo.co.in
Objective:
To put systemic lupus erythematosus (SLE) in remission for a prolonged period.
Methods:
Dexamethasone cyclophosphamide pulse (DCP) therapy was used in a 40-year-old female with SLE of 3 years' duration. DCP therapy comprises an intravenous infusion of 100 mg dexamethasone in 500 ml of 5% glucose over 1-1(1/2) hours on 3 consecutive days along with cyclophosphamide 500 mg in the same drip on the first day. This was repeated at 4-week intervals till 9 months after all the lesions cleared. In between the DCP therapy she was given 50 mg cyclophosphamide orally daily.
Results:
The skin lesions cleared with 11 DCP therapies. There was no relapse 24 months after stopping all treatment.
Conclusion:
DCP therapy appears to put SLE into prolonged remission.
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