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Updated: Jul 3, 2026
Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
[Study on transdermal absorption characteristics of brucine in vitro]
Jun Chen1, Wei Hu, Bao-Chang Cai
1College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China. chenjun75@163.com
Objective:
To study the transdermal absorption characteristics of brucine in vitro.
Methods:
The oil-water partition coefficient of brucine was measured. Drug permeation tests were performed through excised rat skin in improved Franz diffusion cell. Brucine concentration in samples was determined by HPLC.
Results:
The oil-water partition coefficient of brucine was between 4.05 and 5.02 at different temperatures. The permeation rate of 0.5 and 1 mg/ml brucine solution were (1.83 +/- 0.85) and (3.74 +/- 1.54) microg/cm2 x h, respectively. The cumulative permeation ratio in 24 hours were (51.30 +/- 18.51)% and (50.01 +/- 12. 80)%, respectively.
Conclusion:
The research provides experimental datas for the design of transdermal delivery system of brucine.
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