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Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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NK Cells
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Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
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The lymph node in HIV pathogenesis.

Michael M Lederman1, Leonid Margolis

  • 1Center for AIDS Research, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, OH 44118, USA. MXL6@case.edu

Seminars in Immunology
|July 16, 2008
PubMed
Summary
This summary is machine-generated.

Lymphoid tissues are crucial in understanding Acquired Immunodeficiency Syndrome (AIDS) pathogenesis. This review examines evidence implicating lymphoid organs in chronic Human Immunodeficiency Virus type 1 (HIV-1) infection and immune deficiency.

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Peptide-based Identification of Functional Motifs and their Binding Partners
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Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

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Last Updated: Jul 3, 2026

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
11:06

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

Area of Science:

  • Immunology
  • Virology
  • Pathogenesis of infectious diseases

Background:

  • Lymphoid tissue has been recognized for its importance in Acquired Immunodeficiency Syndrome (AIDS) since the epidemic's onset.
  • Generalized lymphadenopathy was an early clinical sign of AIDS.
  • Accumulating evidence over 27 years highlights the central role of lymphoid organs in the pathogenesis of immune deficiency during chronic Human Immunodeficiency Virus type 1 (HIV-1) infection.

Purpose of the Study:

  • To review the accumulated data on the role of lymphoid tissue in HIV-1 infection.
  • To propose a testable model that reconciles existing evidence regarding lymphoid organs and HIV-1 pathogenesis.

Main Methods:

  • Review of existing scientific literature and data.
  • Development of a theoretical model based on the reviewed evidence.

Main Results:

  • The review synthesizes data implicating lymphoid organs in HIV-1 pathogenesis.
  • A testable model is proposed to explain the role of lymphoid tissue in immune deficiency.

Conclusions:

  • Lymphoid organs are critically involved in the pathogenesis of immune deficiency in chronic HIV-1 infection.
  • The proposed model offers a framework for further research into HIV-1 pathogenesis and potential therapeutic strategies targeting lymphoid tissue.