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Hydrodynamics and performance in fluidized bed adsorption
1Institute of Enzymetechnology, Heinrich-Heine University Düsseldorf, D-52404 Jülich, Germany.
Biotechnology and Bioengineering
|November 20, 1995
Summary
Fluidized bed adsorption performance improves with optimized bed dimensions and liquid velocity. Reducing axial mixing in liquid and solid phases enhances capacity and resolution in adsorption processes.
Area of Science:
- Chemical Engineering
- Bioprocess Engineering
- Separation Science
Background:
- Fluidized bed adsorption performance is significantly impacted by hydrodynamics.
- Axial mixing in liquid and solid phases can decrease adsorption capacity and resolution.
Purpose of the Study:
- To investigate axial mixing in the liquid phase of a classified fluidized bed using porous glass granules.
- To evaluate the effect of axial mixing on adsorption performance in real systems at different scales.
Main Methods:
- Analysis of residence time distributions to measure axial mixing in fluidized beds.
- Adsorption experiments with monoclonal antibodies and bovine serum albumin (BSA) at bench and larger scales.
Main Results:
- Reduced axial mixing observed with increased bed height-to-diameter ratio and liquid velocity.
- Increased adsorption capacity correlated with higher bed height-to-diameter ratio.
- Adsorption capacity showed minimal changes across a range of linear velocities, suggesting a shift from dispersion to diffusion control.
Conclusions:
- Optimizing fluidized bed hydrodynamics, specifically reducing axial mixing, is crucial for enhancing adsorption efficiency.
- The bed height-to-diameter ratio is a key parameter for improving capacity.
- Understanding the interplay between dispersion and diffusion is essential for process optimization.
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