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Updated: Jul 3, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
Reflux cough
Kathleen Blondeau1, Daniel Sifrim, Lieven Dupont
1Faculty of Medicine K.U. Leuven, Lab G-I Physiopathology, O&N Gasthuisberg, 3000 Leuven, Belgium.
Abstract:
Cough can be an extraesophageal manifestation of gastroesophageal reflux disease. This article summarizes recent progress in our understanding of the pathophysiology, diagnosis, and treatment of the reflux cough syndrome. Recent studies have provided further evidence for a role of weakly acidic gastroesophageal reflux in inducing cough. It has also been established that although reflux may induce cough, cough may also trigger reflux in some patients, and distinguishing between the two requires objective detection of cough burst (ie, by esophageal manometry). Treatment of the reflux cough syndrome is an issue of ongoing controversy and further studies.
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