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Related Concept Videos

Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Peptide Bonds02:43

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
What are Proteins?01:28

What are Proteins?

Proteins are polymers of amino acids linked together by peptide bonds. Proteins and polypeptides are interchangeably used to refer to long chains of amino acids. However, polypeptides have a molecular weight of fewer than 10,000 daltons, while proteins have greater molecular weight.  Polypeptides with less than 20 amino acids are called oligopeptides or simply peptides. Interactions among the constituent amino acid side chains of proteins help them fold into a stable 3-dimensional structure...
Characteristics and Nomenclature of Copolymers01:24

Characteristics and Nomenclature of Copolymers

Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...

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Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
11:44

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids

Published on: February 21, 2018

Peptides, multimers and polymers.

I Dijkraaf1, H J Wester

  • 1Department of Nuclear Medicine, Technische Universität München, Ismaninger Strasse 22, 81675 München, Germany.

Handbook of Experimental Pharmacology
|July 16, 2008
PubMed
Summary
This summary is machine-generated.

Radiolabeled peptides are excellent for medical imaging and therapy due to their properties. Advanced chemical methods enable targeted delivery, expanding their use in diagnostics and treatment.

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Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

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Last Updated: Jul 3, 2026

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
11:44

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids

Published on: February 21, 2018

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Area of Science:

  • Biomedical imaging
  • Radiopharmaceutical chemistry
  • Molecular imaging

Background:

  • Peptides offer favorable properties and pharmacokinetics for imaging and radiotherapy.
  • Site-specific labeling with radionuclides allows for PET and SPECT imaging without compromising biological integrity.
  • Overexpressed peptide receptors on tumor cells facilitate targeted imaging applications.

Purpose of the Study:

  • To provide an overview of peptide radiopharmaceuticals.
  • To highlight the potential of multimeric and polymeric peptide constructs.
  • To discuss the future applications of radiolabeled peptides in medicine.

Main Methods:

  • Chemical strategies for site-specific radiolabeling.
  • Development of multimeric ligands, polymer-peptide conjugates, and peptide-coated nanoparticles.
  • Review of existing and emerging peptide-based radiopharmaceuticals.

Main Results:

  • Radiolabeled peptides are effective for molecular imaging and targeted therapy.
  • Peptides serve as versatile carriers for diverse signaling units.
  • Advanced constructs like nanoparticles enhance peptide delivery and efficacy.

Conclusions:

  • Radiolabeled peptides are crucial in modern nuclear medicine.
  • Multimeric and polymeric peptide constructs show significant promise for future applications.
  • Further research and clinical evaluation are needed to fully exploit peptide radiopharmaceuticals.