Related Experiment Video
Updated: Jul 3, 2026
06:31
Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response
Published on: October 3, 2019
North American Contact Dermatitis Group patch-test results, 2003-2004 study period
Dermatitis : Contact, Atopic, Occupational, Drug
|July 17, 2008
Summary
Allergic contact dermatitis is common, and patch testing helps identify allergens. Studies show increasing North American allergies to nickel and budesonide, highlighting the need for comprehensive patch testing.
Area of Science:
- Dermatology
- Allergology
- Epidemiology
Background:
- Allergic contact dermatitis (ACD) is a prevalent skin condition with significant occupational and non-occupational impact.
- Patch testing is a crucial diagnostic method for identifying causative allergens in ACD cases.
Purpose of the Study:
- To report the findings of patch testing conducted by the North American Contact Dermatitis Group between January 1, 2003, and December 31, 2004.
- To analyze trends in allergen prevalence and identify potential increases in specific allergies.
Main Methods:
- Standardized patch testing was performed on 5,148 patients across 13 North American centers using a 65-allergen screening series.
- Data collection involved standardized forms, manual verification, data entry, descriptive frequency calculations, and chi-square statistical analysis for trend evaluation.
Main Results:
- A total of 5,148 patients underwent patch testing, with 66.7% showing at least one positive reaction and 44.4% diagnosed with primary allergic contact dermatitis.
- Significant increases in allergies to nickel and budesonide were observed compared to previous reporting periods (2001-2002 and 1994-2002).
- Occupation-related skin disease was identified in 13.1% of patients, with 9,762 positive allergic reactions recorded overall.
Conclusions:
- The prevalence of allergic contact dermatitis due to nickel and budesonide appears to be rising in North America.
- These findings emphasize the continued importance and diagnostic value of extensive allergen screening through patch testing.
