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Updated: Jul 3, 2026
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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Positive patch-test reactions to platinum are rare
Joseph F Fowler1, Jennifer H Perryman, Branden Quinlan
1Division of Dermatology, University of Louisville, Louisville, KY, USA.
Dermatitis : Contact, Atopic, Occupational, Drug
|July 17, 2008
Summary
Positive patch-test reactions to platinum are rare, with only 2 out of 446 patients showing allergies. While uncommon, platinum jewelry can still cause allergic contact dermatitis in some individuals.
Area of Science:
- Dermatology
- Allergology
- Toxicology
Background:
- Contact allergy to metals is prevalent, yet platinum allergy is infrequently assessed.
- Diagnostic patch testing is crucial for identifying contact allergens.
Purpose of the Study:
- To investigate the prevalence of positive patch-test reactions to platinum.
- To assess platinum allergy incidence in a general patient population undergoing patch testing.
Main Methods:
- An unselected cohort of patients with suspected contact dermatitis was enrolled.
- Patch testing was performed using a standard allergen series, including ammonium tetrachloroplatinate at 0.25% concentration.
Main Results:
- Out of 446 patients tested, only two females exhibited positive reactions to platinum.
- One patient had isolated platinum allergy, while the other reacted to multiple metals.
Conclusions:
- Positive patch-test reactions to platinum are infrequent.
- Platinum jewelry is an occasional cause of allergic contact dermatitis.
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