Related Experiment Video
Updated: Jul 3, 2026
06:24
Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis
Published on: October 7, 2021
Ischemic stroke and neurogenesis in the subventricular zone
Rui Lan Zhang1, Zheng Gang Zhang, Michael Chopp
1Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA.
Neuropharmacology
|July 18, 2008
Summary
Stroke triggers neural stem cell activity in the brain's subventricular zone (SVZ). These cells, known as neuroblasts, migrate to aid recovery at the stroke site, highlighting potential therapeutic targets.
Area of Science:
- Neuroscience
- Stem Cell Biology
- Stroke Research
Background:
- The subventricular zone (SVZ) is a niche containing neural stem and progenitor cells.
- These cells generate neuroblasts that migrate to the olfactory bulb for differentiation into interneurons.
- Ischemic stroke is known to induce neurogenesis in the SVZ.
Purpose of the Study:
- To review current data on the cytokinetics, signaling pathways, and vascular niche involved in neural progenitor cell responses after stroke.
- To consolidate understanding of neurogenesis, proliferation, differentiation, and migration of neural progenitor cells post-stroke.
Main Methods:
- Literature review of existing research on SVZ neurogenesis and stroke.
- Analysis of data on cellular kinetics, molecular signaling, and the vascular niche.
- Synthesis of information regarding neural progenitor cell behavior after ischemic injury.
Main Results:
- Ischemic stroke stimulates neurogenesis within the SVZ.
- Newly generated neuroblasts migrate towards the ischemic lesion boundary.
- Specific cytokinetics, signaling pathways, and vascular niche interactions regulate these processes.
Conclusions:
- Post-stroke neurogenesis in the SVZ is a critical endogenous repair mechanism.
- Understanding the regulatory factors (cytokinetics, signaling, vascular niche) is key for therapeutic development.
- Targeting these pathways holds promise for enhancing brain repair after ischemic stroke.
Related Concept Videos
01:15Neurogenesis and Regeneration of Nervous Tissue
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...