Human interferon does not protect cowpea plant cell protoplasts against infection with alfalfa mosaic virus
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Updated: Jul 3, 2026

Direct Agroinoculation of Maize Seedlings by Injection with Recombinant Foxtail Mosaic Virus and Sugarcane Mosaic Virus Infectious Clones
Published on: February 27, 2021
M J Huisman1, H J Broxterman, H Schellekens
1Department of Biochemistry, State University of Leiden, P.O. Box 9505, 2300 RA Leiden, The Netherlands.
Abstract:
Orchansky et al. (P. Orchansky, M. Rubenstein, and I. Sela), Proc. Natl. Acad. Sci. USA 79, 2278-2280, 1982) reported that natural and recombinant human interferon (HuIFN), e.g., HuIFN-beta and -alpha subspecies gamma3, protects plant cells from infection with a plant virus (tobacco mosaic virus). For their study they used tobacco leaf discs as well as tobacco protoplasts. It is now reported that recombinant HuIFN-beta and HuIFN-alpha2 do not significantly decrease alfalfa mosaic virus increase in cowpea mesophyll protoplasts.
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