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Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

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Emotion processing in persons at risk for schizophrenia.

Laura K Phillips¹, Larry J Seidman

¹Department of Psychology, Harvard University, Cambridge, MA 02138, USA. laurak.phillips@gmail.com

Schizophrenia Bulletin

|July 23, 2008

Summary

This summary is machine-generated.

Individuals at high risk for schizophrenia show attenuated emotion processing deficits, similar to those with schizophrenia. Key findings include reduced emotion perception and increased negative affect in at-risk groups.

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Area of Science:

Psychiatry
Neuroscience
Psychology

Background:

Schizophrenia is associated with emotion-processing deficits.
The emotional abnormalities in individuals at risk for schizophrenia remain unclear.
This review synthesizes current knowledge on emotion processing in at-risk populations.

Purpose of the Study:

To review emotion processing in individuals at familial high risk, with schizotypal characteristics, and in the psychosis prodrome.
To examine emotion perception, experience, and expression in these at-risk groups.
To discuss psychophysiological, structural, and functional brain imaging findings related to emotion processing.

Main Methods:

Literature review of studies on emotion processing in schizophrenia at-risk populations.
Analysis of research across emotion perception, experience, and expression.
Inclusion of studies using psychophysiology and neuroimaging with emotion probes.

Main Results:

At-risk individuals exhibit similar, yet less severe, emotion processing abnormalities compared to schizophrenia patients.
Robust findings include reduced emotion perception and increased negative affect.
Self-reported anhedonia is also a significant finding in at-risk groups.

Conclusions:

Individuals at high risk for schizophrenia display attenuated emotion processing deficits.
Future research should further elucidate these emotion abnormalities.
Understanding these deficits may aid in early intervention strategies.