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Updated: Jul 3, 2026

Impact of Common Fruit Juices and Toothbrushing on the Discoloration of Primary Teeth
Published on: March 27, 2026
Instant tooth whitening from a silica toothpaste containing blue covarine
Luisa Z Collins1, Mojgan Naeeni, Suzanne M Platten
1Unilever Oral Care, Quarry Road East, Bebington, Wirral CH63 3JW, UK. luisa.z.collins@unilever.com
Objective:
To measure the instant whitening effect delivered immediately after brushing with a novel silica whitening toothpaste containing blue covarine.
Methods:
A controlled, single blind, cross-over study was performed to compare the tooth colour measured in a group of subjects at baseline and immediately after brushing with a silica whitening toothpaste containing blue covarine versus a clear gel negative control toothpaste. Measurements of tooth colour were made using a mobile non-contact camera-based digital imaging system and expressed as CIELAB and WIO whiteness index.
Results:
Analysis of covariance (ANCOVA) showed that the silica whitening toothpaste containing blue covarine was significantly more effective than the negative control toothpaste (p < 0.05), and made teeth measurably less yellow, less red and overall whiter immediately after brushing.
Conclusion:
A statistically significant reduction in tooth yellowness and improvement in tooth whiteness was measured immediately after brushing with a novel whitening toothpaste containing blue covarine.
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