Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sickle cell vaso-occlusion.

M E Fabry1, D K Kaul

  • 1Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.

Hematology/Oncology Clinics of North America
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Additive effect of red blood cell rigidity and adherence to endothelial cells in inducing vascular resistance.

American journal of physiology. Heart and circulatory physiology·2008
Same author

Sickle red cell adhesion: many issues and some answers.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2008
Same author

Open half-volume quadrature transverse electromagnetic coil for high-field magnetic resonance imaging.

Magnetic resonance in medicine·2005
Same author

Correction of sickle cell disease in transgenic mouse models by gene therapy.

Science (New York, N.Y.)·2001
Same author

Ameliorating effects of fluorocarbon emulsion on sickle red blood cell-induced obstruction in an ex vivo vasculature.

Blood·2001
Same author

Evaluation of serologic disease markers in a population-based cohort of patients with ulcerative colitis and Crohn's disease.

Inflammatory bowel diseases·2001
Same journal

Palliative Therapy for Liver and Biliary Neoplasms.

Hematology/oncology clinics of North America·2026
Same journal

Ablative Therapies for Liver Tumors.

Hematology/oncology clinics of North America·2026
Same journal

Pathology of Liver and Biliary Neoplasms.

Hematology/oncology clinics of North America·2026
Same journal

Minimally Invasive Surgery for Liver and Biliary Tract Neoplasms.

Hematology/oncology clinics of North America·2026
Same journal

Surgical Considerations for Primary Liver Neoplasms.

Hematology/oncology clinics of North America·2026
Same journal

Systemic Therapy for Biliary and Liver Neoplasms: Chemotherapy and Immunotherapy.

Hematology/oncology clinics of North America·2026
See all related articles

Sickle cell vaso-occlusion requires polymerizable cells, but other factors like young red blood cells and K:Cl cotransport activity worsen the disease. Future research may target sickle cell adhesion and vasoactive substances.

Area of Science:

  • Hematology
  • Vascular Biology
  • Pathophysiology

Background:

  • Sickle cell vaso-occlusion is a complex process influenced by factors beyond polymerizable cells.
  • Hemolysis generates young red blood cells that promote adhesion and polymerization.
  • Young red blood cells exhibit increased K:Cl cotransport, exacerbating dehydration and adhesion under acidic conditions.

Purpose of the Study:

  • To explore the multifactorial nature of sickle cell disease progression.
  • To identify key cellular and molecular mechanisms contributing to vaso-occlusion.
  • To inform future therapeutic strategies beyond traditional antisickling agents.

Main Methods:

  • The study reviews existing literature and research findings on sickle cell disease pathophysiology.

Related Experiment Videos

  • It analyzes the role of red blood cell properties, including age and transport activity.
  • It discusses the impact of vasoactive substances and transient occlusions.

    • Main Results:

    • Young red blood cells, a product of hemolysis, are prone to adhesion and polymerization.
    • Elevated K:Cl cotransport in young cells contributes to dehydration and a cycle of hemolysis and adhesion.
    • Transient occlusions can trigger the release of vasoactive substances, expanding the affected area.

    Conclusions:

    • Sickle cell disease progression is modulated by red blood cell characteristics and vasoactive factors.
    • Hydroxyurea, increasing fetal hemoglobin, represents a current therapeutic approach.
    • Future research should focus on inhibiting sickle cell adhesion, K:Cl cotransport, and vasoactive substances for novel treatments.