A new indole alkaloid and anti-inflammatory constituents from Strychnos cathayensis
Jih-Jung Chen1, Yu-Ting Luo, Tsong-Long Hwang
1Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan. jjchen@mail.tajen.edu.tw
Chemistry & Biodiversity
|July 24, 2008
Abstract:
A new indole alkaloid, 11,12-dimethoxyhenningsamine, was isolated from the roots of Strychnos cathayensis, together with 19 known compounds. The structure of this new compound was determined through spectroscopic and mass-spectrometric analyses. Among the isolated compounds, 11-methoxyhenningsamine and aesculetin dimethyl ether exhibited potent inhibition (IC(50) < 5.5 microg/ml) on superoxide-anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B.


