Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distant metastatic foci of infection in adult patients with diabetic foot - not as rare as we think?: case series and review of the literature.

Infectious diseases (London, England)·2021
Same author

Review of high dose vancomycin in the treatment of <i>Clostridioides difficile</i> infection.

Infectious diseases (London, England)·2020
Same author

Treatment of urinary tract infections in the era of antimicrobial resistance and new antimicrobial agents.

Postgraduate medicine·2019
Same author

Postexposure management of infectious diseases.

Cleveland Clinic journal of medicine·2017
Same author

An update on the management of urinary tract infections in the era of antimicrobial resistance.

Postgraduate medicine·2016
Same author

Community-Acquired Pneumonia in Patients With Diabetes Mellitus: Predictors of Complications and Length of Hospital Stay.

The American journal of the medical sciences·2016
Same journal

For Post-stent Patients With Atherosclerotic Coronary Vascular Disease Who Are Taking an Anticoagulant, Adding Aspirin Worsens Outcomes.

American family physician·2026
Same journal

Nausea and Vomiting During Pregnancy.

American family physician·2026
Same journal

Metabolic Dysfunction-Associated Steatotic Liver Disease: Diagnosis and Management.

American family physician·2026
Same journal

Aerobic Exercise Is the Better Exercise Modality for Knee Osteoarthritis.

American family physician·2026
Same journal

Overscreening Leads to Overdiagnosis of MASLD.

American family physician·2026
Same journal

Type 2 Diabetes: Outpatient Insulin Management.

American family physician·2026
See all related articles

Related Experiment Videos

Diabetic foot infection.

Mazen S Bader1

  • 1Memorial University of Newfoundland School of Medicine, St. John's, Newfoundland, Canada. msbader1@hotmail.com

American Family Physician
|July 25, 2008
PubMed
Summary
This summary is machine-generated.

Diabetic foot infections require prompt diagnosis and management to prevent amputation. Treatment involves debridement, antibiotics tailored to infection severity, and addressing underlying conditions like hyperglycemia.

Related Experiment Videos

Area of Science:

  • Infectious Diseases
  • Endocrinology
  • Podiatry

Background:

  • Diabetic foot infections are a major cause of morbidity and amputation.
  • Infections range from mild to severe, with varying bacterial profiles.
  • Accurate diagnosis relies on clinical signs and appropriate culturing.

Purpose of the Study:

  • To outline the classification, diagnosis, and optimal management of diabetic foot infections.
  • To guide antibiotic selection based on infection severity and bacterial pathogens.
  • To emphasize the importance of multidisciplinary care in preventing complications.

Main Methods:

  • Clinical assessment of infection signs and symptoms.
  • Bacteriological culture of tissue specimens (biopsy preferred over swabs).
  • Imaging studies for deep infections or suspected osteomyelitis.

Main Results:

  • Mild/moderate infections often caused by Gram-positive bacteria; severe/chronic infections are polymicrobial.
  • Effective management includes surgical debridement, appropriate antibiotics, and metabolic control.
  • Oral antibiotics suffice for mild infections; IV antibiotics are needed for severe cases.

Conclusions:

  • Prompt and accurate diagnosis is crucial for effective treatment of diabetic foot infections.
  • A combination of surgical, antimicrobial, and metabolic interventions is essential.
  • Adherence to treatment guidelines can reduce amputation rates and improve patient outcomes.