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Related Concept Videos

Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

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Related Experiment Video

Updated: Jul 3, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

Multilocus sequence typing of Candida albicans isolates from animals.

Mette D Jacobsen1, Marie-Elisabeth Bougnoux, Christophe d'Enfert

  • 1Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Research in Microbiology
|July 26, 2008
PubMed
Summary

Animal and human Candida albicans isolates show distinct genetic strain types. This suggests specific C. albicans strains are adapted to animal hosts, though not completely separated genetically.

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Last Updated: Jul 3, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

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Visualization of Candida albicans in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization

Published on: November 5, 2019

Area of Science:

  • Medical Mycology
  • Genetics
  • Epidemiology

Background:

  • Candida albicans is an opportunistic fungal pathogen with a broad host range.
  • Understanding strain diversity is crucial for tracking fungal transmission and adaptation.

Purpose of the Study:

  • To compare multilocus sequencing strain types of animal-derived Candida albicans with human isolates.
  • To investigate potential genetic selection of C. albicans strains in non-human animal hosts.

Main Methods:

  • Multilocus sequencing was used to determine strain types.
  • Comparative analysis of 43 animal isolates (mammals, avian) against human isolates (total 1580, and 675 from same regions).
  • Nearest-neighbour analysis was performed on a subset of animal and human isolates.

Main Results:

  • Significant differences in clade distribution were observed between animal and human C. albicans isolates.
  • A statistical trend indicated genetic selection of distinct C. albicans strain types adapted to animal hosts.
  • Complete genetic separation between animal and human C. albicans strains was not observed.

Conclusions:

  • Candida albicans exhibits host-associated genetic differentiation.
  • Animal reservoirs may harbor distinct C. albicans strains, influencing epidemiology.
  • Further research is needed to elucidate the mechanisms of host adaptation and potential transmission dynamics.