Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nervous Tissue: Glial Cells

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...

Diencephalon: Hypothalamus and Coordination

Diencephalon: Hypothalamus and Coordination

The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...

Glial Cells

Glial Cells

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Live-Cell SICM Imaging: An Introductory Guide for New Users.

Analytical chemistry·2026

Same author

Astrocytic mGluR5 Regulation of Synaptic Transmission is Activity-Dependent in Adult Rats.

Glia·2026

Same author

D-Serine's Journey Between Stars and Synapses.

Neurochemical research·2025

Same author

Astrocytic EphB3 receptors regulate d-serine-gated synaptic plasticity and memory.

Progress in neurobiology·2025

Same author

MRI R2* captures inflammation in disconnected brain structures after stroke: a translational study.

Brain : a journal of neurology·2025

Same author

Activation of ionotropic and group I metabotropic glutamate receptors stimulates kisspeptin neuron activity in mice.

Journal of neuroendocrinology·2024

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

Published on: June 20, 2018

Neuron-glia interactions in the rat supraoptic nucleus.

Stéphane H R Oliet¹, Aude Panatier, Richard Piet

¹Neuroscience Research Center, Inserm U862, Bordeaux, France; Université Victor Segalen Bordeaux 2, Bordeaux, France.

Progress in Brain Research

|July 29, 2008

Summary

Activity-dependent remodeling of the hypothalamo-neurohypophysial system alters glial wrapping around magnocellular neurons. This impacts astrocytic functions, affecting glutamatergic transmission and neuronal excitability.

More Related Videos

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

Published on: November 2, 2020

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

Related Experiment Videos

Last Updated: Jul 3, 2026

Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

Published on: June 20, 2018

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

Published on: November 2, 2020

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

Area of Science:

Neuroscience
Cell Biology
Neuroendocrinology

Background:

The adult hypothalamo-neurohypophysial system exhibits activity-dependent morphological changes.
Glial cells, particularly astrocytes, ensheath magnocellular neurons and influence their function.
The functional impact of altered glial enwrapping on neuronal physiology is not fully understood.

Purpose of the Study:

To investigate the functional consequences of glial environment modifications on magnocellular neurosecretory cells.
To explore how reduced astrocytic coverage affects synaptic physiology in the SON (supraoptic nucleus).

Main Methods:

The study focuses on analyzing the repercussions of glial environment modifications.
It examines the role of astrocytes in neurotransmitter uptake, extracellular space regulation, and gliotransmission.

Main Results:

Reduced astrocytic coverage in the SON impacts key astrocytic functions.
These functions include glutamate uptake, regulation of neuroactive substance diffusion, and gliotransmitter release.
Neuron-glial anatomical reorganization leads to altered glutamatergic transmission.

Conclusions:

Modifications in astrocytic coverage significantly affect magnocellular neuron physiology at the synaptic level.
Altered glutamatergic transmission due to neuron-glial reorganization may be crucial for hypothalamo-neurohypophysial system function.