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Updated: Jul 3, 2026

Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
[Premature ovarian failure: which approaches?]
J Belaisch-Allart1, J-M Mayenga, I Grefenstete
1Service de gynécologie-obstétrique et médecine de la reproduction, centre hospitalier des Quatre-Villes, Site-de-Sèvres, 141, Grande-Rue, 92318 Sèvres cedex, France. jbelaisch@promptomail.com
Abstract:
Premature ovarian failure (POF) occurs in one case of 10,000 in women below the age of 20, one case of 1000 below 30 and 1% in women before the age of 40. In 80% of POF cases, the etiology is unknown, except for Turner syndrome. Spontaneous fertility is very weak, only 3 to 10% of the patients will have natural conception. If the diagnosis is confirmed, ovarian stimulation usually fails. When fertility is desired, the alternative treatments are oocyte and/or embryo donation or adoption and "learn to be happy just in couple". Psychological management is always necessary.
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