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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Updated: Jul 3, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

Stem cells for tooth engineering.

G Bluteau¹, H U Luder, C De Bari

¹Department of Orofacial Development and Structure, Institute of Oral Biology, ZZMK, Faculty of Medicine, University of Zurich, Plattenstrasse 11, CH 8032 Zurich, Switzerland. gilles.bluteau@zzmk.uzh.ch

European Cells & Materials

|August 2, 2008

Summary

This summary is machine-generated.

This review explores using various stem cells for in vitro tooth regeneration. While promising, challenges like rejection and controlled development limit current dental applications.

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Primary Culture of Dental Pulp Stem Cells

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Published on: May 5, 2023

Area of Science:

Dental research
Regenerative medicine
Stem cell biology

Background:

Tooth development involves complex epithelial-mesenchymal interactions.
Mesenchymal stem cells show dentinogenic potential, but epithelial stem cells' role is underexplored.
Epithelial stem cells are crucial for tooth initiation and enamel formation.

Purpose of the Study:

To review stem cell sources for in vitro tooth generation.
To assess the efficiency of different stem cell types in dental regeneration.
To highlight challenges and future directions in bio-dental reconstruction.

Main Methods:

Review of studies utilizing embryonic, post-natal, and adult stem cells for tooth regeneration.
Assessment of in vitro dentin and enamel formation capabilities.
Analysis of parameters affecting clinical application of regenerated teeth.

Main Results:

Various stem cells demonstrate significant regenerative potential for dental tissues.
Mesenchymal stem cells are well-studied for dentinogenesis.
Epithelial stem cells are essential but less investigated for enamel production.

Conclusions:

Stem cell-based approaches offer promising avenues for dental reconstruction.
Clinical application faces hurdles including immune rejection, cell behavior control, and aesthetic outcomes.
Further research is needed to overcome limitations for successful in vivo tooth regeneration.