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Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

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Bioengineered tooth emulation systems for regenerative and pharmacological purposes.

P Pagella, A Cordiale, G D Marconi

¹nstitute of Oral Biology, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland. thimios.mitsiadis@zzm.uzh.ch.

European Cells & Materials

|May 10, 2021

Summary

Dental regenerative therapies face challenges due to a lack of complex human dental tissue models. Innovative in vitro systems like bioreactors and organ-on-a-chip devices show promise for advancing dental tissue regeneration and drug testing.

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Last Updated: Nov 6, 2025

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

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Published on: April 13, 2022

Propagation of Dental and Respiratory Cells and Organs in Microgravity

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Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

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Published on: July 8, 2021

Area of Science:

Biomaterials Science
Regenerative Medicine
Dental Research

Background:

Dental pathologies arise from genetic conditions, injuries, caries, and periodontal diseases.
Current treatments using inert materials fail to fully restore dental tissue physiology.
Dental mesenchymal stem cells offer potential for tissue regeneration but clinical applications are limited.

Purpose of the Study:

To review innovative in vitro culture systems for modeling human dental tissues.
To explore the potential of these systems for dental regeneration.
To assess their utility in drug testing applications.

Main Methods:

Focus on in vitro culture systems, specifically bioreactors and "organ-on-a-chip" microfluidic devices.
Discuss the development of systems that emulate human tooth physiology.
Review existing literature on modeling complex dental tissues.

Main Results:

Advanced in vitro systems are crucial for overcoming limitations in dental regenerative therapies.
Bioreactors and microfluidic devices offer promising platforms for mimicking dental tissue complexity.
These systems facilitate research into dental tissue regeneration and drug screening.

Conclusions:

The development of sophisticated in vitro models is essential for advancing dental regenerative medicine.
Bioreactors and organ-on-a-chip technologies represent key innovations in dental tissue engineering.
These platforms hold significant potential for future dental regeneration strategies and pharmaceutical testing.