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Hydrogen-bonding layer protecting polyelectrolyte capsules and its mechanical property study with atomic force

Liqin Ge1, Xing Wang, Long Ba

  • 1State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China.

Journal of Nanoscience and Nanotechnology
|August 7, 2008
PubMed
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Hydrogen-bonding in polyelectrolyte capsules enhances their mechanical properties, making them significantly harder. Atomic Force Microscopy (AFM) confirmed these improved elastic properties for microcapsule applications.

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Layer-by-layer (LbL) self-assembly is a versatile technique for fabricating multilayered polyelectrolyte microcapsules.
  • Understanding the mechanical properties of these capsules is crucial for their application in drug delivery and sensing.
  • Hydrogen bonding interactions can influence the structural integrity and mechanical response of polymer-based materials.

Purpose of the Study:

  • To fabricate hydrogen-bonding multilayered polyelectrolyte capsules using the LbL method.
  • To investigate the elastic properties and Young's modulus of these capsules.
  • To compare the mechanical properties of hydrogen-bonding capsules with pure polyelectrolyte capsules.

Main Methods:

  • Fabrication of microcapsules (approx. 6 microm) via layer-by-layer self-assembly.

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  • Morphological characterization using Scanning Electron Microscopy (SEM), Confocal Laser Scanning Microscopy (CLSM), and Atomic Force Microscopy (AFM).
  • Elastic property measurement using AFM by pressing the capsule with a cantilever equipped with a glass bead to obtain force curves and calculate Young's modulus.

    • Main Results:

    • The morphology of the fabricated capsules was successfully characterized by SEM, CLSM, and AFM.
    • AFM force measurements yielded a Young's modulus of 170 MPa for the hydrogen-bonding capsules under loading.
    • The study demonstrated that the developed model accurately predicts the elastic deformation of microcapsules.
    • Hydrogen-bonding incorporation resulted in a measurable increase in the hardness of the multilayered polyelectrolyte capsules compared to those without hydrogen bonding.

    Conclusions:

    • Hydrogen-bonding multilayered polyelectrolyte capsules can be effectively fabricated using the LbL self-assembly method.
    • AFM is a suitable technique for probing the elastic properties of microcapsules, with cantilever stiffness influencing accuracy.
    • The presence of hydrogen-bonding layers significantly enhances the mechanical strength and stiffness of polyelectrolyte capsules.