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Published on: January 22, 2020
Foxp3 expression in cutaneous T-cell lymphocytic infiltrates
Garron J Solomon1, Cynthia M Magro
1Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA.
Journal of Cutaneous Pathology
|August 7, 2008
Summary
Regulatory T cells (Treg cells), marked by Foxp3, may control skin T-cell proliferation. A lack of T-regulatory function may permit T-cell disorders, impacting conditions like lymphoma.
Area of Science:
- Immunology
- Dermatology
- Oncology
Background:
- Regulatory T cells (Treg cells) are crucial for immune homeostasis.
- Foxp3 is the canonical marker for identifying Treg cells.
- Treg cells regulate T-cell function and proliferation.
Purpose of the Study:
- To evaluate Foxp3 expression in various cutaneous T-cell infiltrates.
- To investigate the potential role of Treg cells in skin T-cell disorders.
Main Methods:
- Analysis of Foxp3 expression in 95 cases of cutaneous T-cell infiltrates.
- Categorization of cases into reactive, prelymphomatous dyscrasia, and T-cell lymphoma groups.
Main Results:
- Foxp3 expression varied across categories: <10% in dermatomyositis/lupus, 23% in hypersensitivity, 0% in graft-vs.-host disease, 16% in dyscrasias, and 11% in lymphomas.
- Aggressive lymphomas showed very low Foxp3+ cells (<5%).
- Monoclonal variants of pityriasis lichenoides chronica and pigmented purpuric dermatosis had reduced Foxp3+ T cells.
Conclusions:
- Treg cells may play a role in limiting T-cell proliferation in the skin.
- Deficient T-regulatory function could predispose to T-cell disorders.
- Further research into Treg cell function in cutaneous T-cell disorders is warranted.
