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Updated: Jul 3, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
Oxidative and antioxidant changes during formation of unstable atherosclerotic plaque
Yu I Ragino1, A M Chernyavski, Ya V Polonskaya
1Institute of Therapy, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. ragino@online.nsk.su
Abstract:
Oxidative and antioxidant parameters (content of LPO products and oxidized proteins, initial level of paraoxonase, content of alpha-tocopherol, retinol, and beta-carotene) were studied at different stages of atherosclerotic foci development in coronary arteries: intact intima, lipid spot, stable young plaque, unstable plaque, stable plaque with fibrosis/ calcinosis, and in various types of unstable plaques. The most typical sign of unstable plaques is high level of LPO products and low retinol content.
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