Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

Higher Mental Functions of Brain: Learning and Memory

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or playing an...

Storage

Storage

A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze each...

Understanding Memory

Understanding Memory

Memory is the retention of information or experiences over time, facilitated through three main processes: encoding, storage, and retrieval. Encoding is the process of inputting information into the memory system. For instance, when listening to a lecture, watching a play, reading a book, or having a conversation, the brain is actively encoding information. This initial stage involves transforming sensory input into a form that can be processed and stored by the brain. Various factors, such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Place cells in CA1 lack topographical organization of firing locations.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Dynamics of Dentate Gyrus Place Cells and Dentate Spikes Signal Spatial and Nonspatial Changes in Environments.

bioRxiv : the preprint server for biology·2025

Same author

CA2 neurons show abnormal responses to social stimuli in a rat model of Fragile X syndrome.

bioRxiv : the preprint server for biology·2025

Same author

Event structure sculpts neural population dynamics in the lateral entorhinal cortex.

Science (New York, N.Y.)·2025

Same author

Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025

Same author

Left-right-alternating theta sweeps in entorhinal-hippocampal maps of space.

Nature·2025

Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026

Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026

Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026

Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026

Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026

Same journal

The neural basis of laughter.

Trends in neurosciences·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

Understanding memory through hippocampal remapping.

Laura Lee Colgin¹, Edvard I Moser, May-Britt Moser

¹Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway. laura.colgin@cbm.ntnu.no

Trends in Neurosciences

|August 9, 2008

Summary

This summary is machine-generated.

Memory interference, a cause of forgetting, may be overcome by neural processes like remapping in the hippocampus. This involves creating distinct brain representations to minimize memory overlap and improve recall.

More Related Videos

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

Published on: August 2, 2024

Related Experiment Videos

Last Updated: Jul 3, 2026

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

Published on: August 2, 2024

Area of Science:

Neuroscience
Cognitive Science
Memory Research

Background:

Memory interference is a primary cause of forgetting.
The brain must balance creating distinct memory representations with retrieving memories using similar cues.
The neural mechanisms underlying this balance remain largely unknown.

Purpose of the Study:

To explore how the brain manages memory interference.
To investigate the role of hippocampal place cell remapping in memory.
To understand how distinct neural representations aid memory storage and retrieval.

Main Methods:

Review of studies on hippocampal place cell remapping in rodents.
Analysis of how remapping contributes to decorrelating neural signals.
Connecting remapping mechanisms to principles of memory formation and interference.

Main Results:

Remapping in hippocampal place cells involves forming distinct neural representations.
These distinct representations arise from minor changes in hippocampal inputs.
Remapping may reflect general processes of signal decorrelation.

Conclusions:

Hippocampal remapping offers insights into overcoming memory interference.
Decorrelation processes are crucial for storing numerous similar experiences with minimal interference.
Understanding remapping can elucidate mechanisms for robust memory formation.