[Oocyte donation in Turner syndrome]

Area of Science:

• Reproductive endocrinology and genetics
• Maternal-fetal medicine
• Cardiovascular health in pregnancy

Context:

• Turner syndrome (TS) accounts for approximately 10% of oocyte donation cases.
• Pregnancy outcomes in TS patients undergoing oocyte donation are generally favorable with sufficient endometrial preparation.
• TS is associated with significant somatic abnormalities that increase risks for obstetrical complications and mortality, notably aortic dissection.

Purpose:

• To highlight the necessity of precise pre-donation medical evaluations for Turner syndrome patients.
• To outline essential antenatal care strategies for mitigating severe complications in pregnant TS patients.
• To optimize oocyte donation protocols for women with Turner syndrome.

Summary:

• Oocyte donation offers a viable path to pregnancy for women with Turner syndrome, achieving satisfactory pregnancy rates when endometrial receptivity is optimized.
• Despite positive pregnancy rates, Turner syndrome patients face heightened risks of obstetrical complications and mortality, particularly cardiovascular events like aortic dissection.
• Rigorous pre-donation screening and specialized obstetric care during pregnancy are imperative to ensure patient safety and minimize risks.

Impact:

• Informs clinical practice regarding the management of Turner syndrome patients undergoing oocyte donation.
• Emphasizes the importance of multidisciplinary care involving reproductive specialists, cardiologists, and obstetricians.
• Aims to improve safety and outcomes for a specific patient population seeking assisted reproduction.